When cells find themselves in a tight spot, the cell cycle regulator p21 halts the cell cycle, buying cells time to repair the damage, or if all else fails, to initiate programmed cell…
The moment we open our eyes, we perceive the world with apparent ease. But the question of how neurones in the retina encode what we 'see' has been a tricky one. A key obstacle to understanding…
The current pace of population ageing is without parallel in human history but surprisingly little is known about the human ageing process, because lifespans of eight decades or more…
Reprogramming adult cells to recapture their youthful 'can-do-it-all' attitude appears to leave an indelible mark, found researchers at the Salk Institute for Biological Studies. When…
In analysing the molecular sensor for the plant growth hormone brassinolide, researchers at the Salk Institute for Biological Studies discovered that although plants took an evolutionary…
Among stem cell biologists there are few better-known proteins than nestin, whose very presence in an immature cell identifies it as a 'stem cell,' such as a neural stem cell. As helpful…
Glioblastoma, the most common and lethal form of brain cancer and the disease that killed Massachusetts Senator Ted Kennedy, resists nearly all treatment efforts, even when attacked…
In making your pro-longevity resolutions, like drinking more red wine and maintaining a vibrant social network, here's one you likely forgot: dialling down your mitochondria. It turns…
Researchers at the Salk Institute for Biological Studies have discovered how AMPK, a metabolic master switch that springs into gear when cells run low on energy, revs up a cellular…
In addition to fast food, desk jobs, and inertia, there is one more thing to blame for unwanted pounds-our genome, which has apparently not caught up with the fact that we no longer…